Molecular Pharmacology of the Metabotropic Glutamate Receptors

摘要: (S)-Glutamate (Glu) is the major excitatory neurotransmitter in central nervous system (CNS), where it plays a key role wide range of brain functions, such as neural plasticity, memory formation, and development (1). On other hand, Glu can also act neurotoxin under certain conditions, especially when energy supply reduced. Excessive glutamatergic signaling has been implicated acute neurotoxic insults ischemia, stroke, epilepsy, multiple chronic neurodegenerative states like Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s chorea, dementia. Furthermore, mechanisms have proposed to contribute psychiatric disorders schizophrenia anxiety, modulation transmission shown be beneficial on forms pain (2–4).