Liver Disease in Infants Receiving Total Parenteral Nutrition

摘要: Progressive cholestasis and abnormal elevations of liver enzymes occurred in one third 92, mostly preterm, newborn infants who received total parenteral nutrition (TPN) with Protein hydrolysates, synthetic L-amino acids, intravenous fat emulsion. The amino acid plus emulsion was not superior to the protein hydrolysate preventing disease. function returned normal after discontinuation TPN, which suggests a causal relationship. Hepatic microscopy 12 14 examined. main features were progressive portal tract fibrosis infiltration, led failure death two infants. In our experience, disease is major matabolic complication TPN