Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives
作者： Miguel F. Braña , Ana Gradillas , Angel G. Ovalles , Berta López , Nuria Acero
DOI: 10.1016/J.BMC.2005.09.059
关键词:
摘要: New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, with a bisindolylpyrazolone framework and substituted on pyrazolone nitrogens N,N-dialkylaminoalkyl side chain, were synthesized evaluated for growth-inhibitory properties in several human cell lines. Many showed inhibition of TNF-α production response tumor promotor TPA HL-60 cells. The apoptotic activity HeLa cells has been examined these compounds.
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