Novel Method for Determination of Partition Coefficients of Penicillins and Cephalosporins by High-pressure Liquid Chromatography

作者: Tsukinaka Yamana , Akira Tsuji , Etsuko Miyamoto , Osamu kubo

DOI: 10.1002/JPS.2600660541

关键词:

摘要: Newly defined lipophilic indexes, log k', of a series of penicillins and cephalosporins were rapidly and reliably determined by re‐versed‐phase high‐pressure liquid chromatography (…

参考文章(12)
John M. McCall, Liquid-lipquid partition coefficients by high-pressure liquid chromatography. Journal of Medicinal Chemistry. ,vol. 18, pp. 549- 552 ,(1975) , 10.1021/JM00240A003
G.L. Biagi, A.M. Barbaro, M.C. Guerra, M.F. Gamba, Partition data of cephalosporins determined by means of reversed-phase thin-layer chromatography Journal of Chromatography A. ,vol. 44, pp. 195- 198 ,(1969) , 10.1016/S0021-9673(01)92522-1
A.E. Bird, A.C. Marshall, Correlation of serum binding of penicillins with partition coefficients. Biochemical Pharmacology. ,vol. 16, pp. 2275- 2290 ,(1967) , 10.1016/0006-2952(67)90215-8
Corwin. Hansch, Toshio. Fujita, p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure Journal of the American Chemical Society. ,vol. 86, pp. 1616- 1626 ,(1964) , 10.1021/JA01062A035
Gian L. Biagi, Maria C. Guerra, Anna M. Barbaro, Maria F. Gamba, Influence of lipophilic character on the antibacterial activity of cephalosporins and penicillins. Journal of Medicinal Chemistry. ,vol. 13, pp. 511- 516 ,(1970) , 10.1021/JM00297A038
G.L. Biagi, A.M. Barbaro, M.F. Gamba, M.C. Guerra, Partition data of penicillins determined by means of reversed-phase thin-layer chromatography. Journal of Chromatography A. ,vol. 41, pp. 371- 379 ,(1969) , 10.1016/0021-9673(64)80150-3
R. Nelson Smith, Copwin Hansch, Matthew M. Ames, Selection of a Reference Partitioning System for Drug Design Work Journal of Pharmaceutical Sciences. ,vol. 64, pp. 599- 606 ,(1975) , 10.1002/JPS.2600640405
A.E. Bird, A.C. Marshall, Reversed-phase thin-layer chromatography and partition coefficients of penicillins Journal of Chromatography A. ,vol. 63, pp. 313- 319 ,(1971) , 10.1016/S0021-9673(01)85644-2
A.E. Bird, Hansch Analysis of Interaction of Haptens with Benzylpenicilloyl Antibodies Journal of Pharmaceutical Sciences. ,vol. 64, pp. 1671- 1674 ,(1975) , 10.1002/JPS.2600641018