Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.

摘要: The importance of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal and hepatic metabolism has been unclear. We now demonstrate that ACAT2 is the major ACAT mouse small intestine liver, suggest deficiency profound effects on mice fed a cholesterol-rich diet, including complete resistance to diet-induced hypercholesterolemia gallstone formation. underlying mechanism involves lack resultant reduced capacity absorb cholesterol. Our results indicate an important role response dietary cholesterol, inhibition may be useful strategy for treating or gallstones.