Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system.

摘要: Importance Case reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis other demyelinating diseases. Objective To investigate if quadrivalent HPV (qHPV) is associated with an increased risk Design, Setting, Participants Using nationwide registers we identified cohort all females aged 10 years to 44 in Denmark Sweden, followed up from 2006 2013, information on qHPV vaccination, data incident diagnoses The primary analysis used design including vaccinated unvaccinated study participants. A secondary self-controlled case-series only cases. Both analyses 2-year period following vaccination. Exposures Information was obtained through the national prescription registers. Main Outcomes Measures outcomes were composite end point Incidence rate ratios estimated using Poisson regression, comparing rates events periods time periods. Results included 3 983 824 females, among whom 789 082 received total 1 927 581 vaccine doses. During follow-up, 4322 cases 3300 diseases identified, which 73 90, respectively, occurred within period. In analysis, there no (crude incidence rates, 6.12 events/100 000 person-years [95% CI, 4.86-7.69] 21.54 20.90-22.20] for periods; adjusted ratio, 0.90 0.70-1.15]) or 7.54 6.13-9.27] 16.14 15.58-16.71]; 1.00 0.80-1.26]) Similarly, found (multiple sclerosis: 1.05 0.79-1.38]; diseases: 1.14 0.88-1.47]). Conclusions Relevance this coverage 2 Scandinavian countries, not These findings do support concerns about causal relationship