Polycyclic Aromatic Hydrocarbon-DNA Adducts and Survival among Women with Breast Cancer

摘要: Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested link between elevated levels of PAH-DNA adducts breast cancer incidence. An association survival among cases has not been previously reported. We conducted analysis women with newly diagnosed invasive 1996 1997, enrolled the Long Island Breast Cancer Study Project. DNA was isolated from blood samples that were obtained shortly after diagnosis before treatment, assayed for using an ELISA. Among 722 adduct measurements, 97 deaths (13.4%) all causes 54 (7.5%) due to reported National Death Index (NDI) by December 31, 2002. Using Cox proportional hazards models controlling age at diagnosis, we did find evidence all-cause mortality (hazard ratio (HR) = 0.88; 95% confidence interval (CI): 0.57–1.37), or (HR 1.20; CI: 0.63–2.28) strongly associated detectable compared non-detectable adducts; additionally, no dose-response observed. subgroup treatment data (n=520), over two-fold higher those receiving radiation, but reduced hormone therapy users. Results this large population-based study do provide strong support cancer, except perhaps radiation treatment.