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    Endogenous Alanine, Gh~tamate, Aspartate, and Glutamine in the Perfused Guinea-Pig Heart: Effect of Substrates and Cardioactive Agents

    作者： Gailis

    DOI:

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    摘要: CAILPS, L., and BENMOUYAT,, E. Endogenous alanine, glutamate, aspartate, glutamine in the perfused guinea-pig heart: effect of substrates cardioactive agents. Can. J. Biochem. 51, 11-20 (1973 j: The isolated, .nonworking heart was with "@-labelled glucose, pyruvate, acetate. Labelled total andBglutamine were measured. alanine content varied directly medium pyruvate concentration. sum concentrations glutamate aspartate inversely constant under most perfusion conditions, but loss into increased presence ouabain, low Ca2+ concentration, or malonate. amino acids from remained all conditions except malonate, when it decreased. Labelling 14C-labelled indicated that exchanged readily their cr-0x0 acids. However, only 30% during 1 h; this proportion little metabolic flux. results indicate a closed system, changes are brought about by transamination.

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    来源期刊
    • 2007 年,
    • Volume: , Issue: ,
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