Multi-analytical studies about physico-chemical properties of Ni(II)-vitamin B6 coordination compounds and their CT-DNA interactions

作者: Agnieszka Chylewska , Małgorzata Biedulska , Mariusz Makowski

DOI: 10.1016/J.MOLLIQ.2017.08.100

关键词:

摘要: Abstract Two coordination compounds and their structural characterization of [Ni(PM) 2 ]Cl [Ni(PL) have been studied. Pyridoxamine (PM) pyridoxal (PL) denote individual vitamers vitamin B 6 both demonstrated bidentate nature inside the complexes. The acid-base behavior mentioned complexes possible interactions with biomolecules in solutions never reported. Here, UV-spectroscopic, potentiometric, cyclic voltammetric studies carried out on interaction Ni(II)-vitamer protons as well calf thymus -DNA (CT-DNA) aqueous medium. acidity constants values studied determined compared. potentiometric pHmetric-spectrophotometric microtitrations were at same conditions temperature pH range, 25 °C 1.72–11.68, respectively. procedural decomposition temperatures given considered relation to structures examined complete description . CT-DNA binding potential Ni(II) was by absorption spectroscopy voltammetry methods. Mechanism investigation has that could interact grooving mode, which stabilized hydrogen bond van der Waals forces.

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