Myeloid dendritic cells with elevated CD1c expression in non-infectious uveitis patients exhibited mature phenotype through the regulation of TNFa-p38 MAPK pathway (HUM1P.273)

摘要: Our longitudinal data has shown that the level of CD1c+ myeloid dendritic cells 1 (mDC1) from peripheral blood reflects disease activity in autoimmune non-infectious uveitis patients. However, role mDC1 is not clear Here, we demonstrate patients with (n=74) was increased compared to age and gender-matched healthy controls (n=96). The exhibited high HLADR expression less antigen uptake. were further divided into two subpopulations based on CD1c expression. CD1chi subpopulation showed uptake higher CD1clo subpopulation. Importantly, significantly By utilizing monocyte-derived (MoDCs) for vitro studies, MoDCs levels induced more CD4+ T helper cell activation proliferation. TNFa, patient sera, reduced a dose-dependent manner phosphorylated p38 MoDCs. A inhibitor inhibited during differentiation monocytes. In conclusion, maturation marker mDC1, correlated activity. low are mediated by TNFa-activated MAPK pathway.