Biology of HPV in HIV Infection

摘要: HIV-positive men and women are at increased risk of anogenital oral HPV infection. The risks for HPV-associated high-grade intra-epithelial neoplasia (IN) cancer also increased. prevalence oral, anal, cervical infection in individuals compared with HIV-negative increases progressively lower CD4+ levels, as does incident IN. In contrast to IN, development is not related level. With increasing grades IN cancer, the proportion tissues copy-number abnormalities (CNA) increases, one most common genetic changes being amplification chromosome 3q. presence CNA associated integration DNA into host genome, loss E2 and/or rearrangement. This suggests a link between HPV-induced chromosomal instability mediated through de-repressed E6 E7 expression consequent functional protein. addition, epigenetic occur frequency such hypermethylation leading down-regulation potential tumor suppressor genes. Analysis these data together that immune suppression plays more prominent role earlier stages disease, up including Persistent may be strongly cumulative effect resulting changes. There few suggest direct HIV pathogenesis neoplasia, but HIV-associated attenuation HPV-specific responses allow persistence sufficient time accumulation important progression cancer.