Metal-Free, Site-Selective Addition to Ynones: An Approach to Synthesize Substituted Quinoline Derivatives.

作者: Zi-Sheng Chen , Fang Yang , Huibo Ling , Mengxue Li , Jin-Ming Gao

DOI: 10.1021/ACS.ORGLETT.6B02813

关键词:

摘要: An efficient two component cycloaddition reaction to synthesize various substituted quinoline derivatives was developed. Ynone 1 functionalizated by N-oxide attacking the C3-oxetium site and C3-site regioselectively give 3 4. Analogues 3k 4v have a high binding constant with Hg2+ in CH3CN.

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