Pharmacotherapy Approaches in Nontuberculous Mycobacteria Infections

摘要: Nontuberculous mycobacteria (NTM) comprise a heterogeneous group of organisms, with only small subset known to cause disease in humans. Although NTM infection is not reportable disease, both the increasing clinical recognition and recent advancements laboratory diagnostic capabilities infections immunocompromised immunocompetent patients are rapidly evolving. We reviewed antimicrobial agents used treat most frequently encountered examined optimized drug dosing strategies, toxicity profiles, drug-drug interactions, role therapeutic monitoring. Antimicrobial susceptibility testing patient monitoring on therapy were also examined. PubMed review published literature management select pathogens, common syndromes since 2000, pharmacokinetic principles 1990. included trials, systematic reviews, guidelines, observational studies when applicable. The prolonged duration necessity for combination forms can be problematic many patients. A multidisciplinary care team that includes pharmacy engagement may help increase rates optimal tolerability successful treatment completion.