Translating Animal Models of Obesity and Diabetes to the Clinic

摘要: Abstract Animal models of disease and drug action have played a vital role in the translation effects CNS drugs from bench to bedside. Because limitations our ability understand molecular mechanisms underlying pathophysiology human brain, we rely on animal provide insight into these identify promising targets for development therapeutics various diseases. In this chapter, discuss key attributes valid model. We also elaborate several examples used preclinical research, including spontaneous, selectively bred, genetic, surgical, pharmacological, behavioral, or environmental models. Finally, describe how been discovery obesity therapeutics.