Rhythm control strategies were not better than rate control strategies for atrial fibrillation

摘要: (2002) N Engl J Med 347, 1825. Wyse DG, Waldo AL, DiMarco JP, et al. . A comparison of rate control and rhythm in patients with atrial fibrillation. ; : –33 . [OpenUrl][1][CrossRef][2][PubMed][3][Web Science][4] 
 QUESTION: Is a long term strategy as effective for fibrillation (AF)? Randomised {allocation concealed*}†, blinded {outcome assessors monitoring committee}†,* controlled trial mean follow up 3.5 years (Atrial Fibrillation Follow Investigation Rhythm Management [AFFIRM] study). 213 clinical sites North America. 4060 who were ≥65 age (mean 70 y, 61% men) or had other risk factors stroke death; AF that was likely to be recurrent, cause illness death, warranted treatment; no contraindications anticoagulants. 98%. 2027 allocated using the following drugs alone combination selected by treating physician: β blockers, calcium channel blockers (verapamil diltiazem), digoxin. Target heart ≤80 beats/min at rest ≤110 beats/minute during 6 minute walk test. Continuous … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DThe%2BAtrial%2BFibrillation%2BFollow-up%2BInvestigation%2Bof%26rft.auinit1%253D%2B%26rft.volume%253D347%26rft.issue%253D23%26rft.spage%253D1825%26rft.epage%253D1833%26rft.atitle%253DA%2BComparison%2Bof%2BRate%2BControl%2Band%2BRhythm%2BControl%2Bin%2BPatients%2Bwith%2BAtrial%2BFibrillation%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa021328%26rft_id%253Dinfo%253Apmid%252F12466506%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa021328&link_type=DOI [3]: /lookup/external-ref?access_num=12466506&link_type=MED&atom=%2Febmed%2F8%2F5%2F140.atom [4]: /lookup/external-ref?access_num=000179596900002&link_type=ISI