Letter to the Editor Response

摘要: We appreciate the opportunity to reply comments by Drs Pat F. Bass and Chaitanya Pant. Pant note that diarrhea is single most remarkable clinical manifestation of Clostridium difficile infection (CDI), yet only 61% our patients had diarrhea. CDI often described in who have contact with a medical facility. The population whose charts we reviewed no discernable facility prior their colonoscopy. It possible community setting less severe than acquired hospital may even different manifestations. also been colonized not because they asymptomatic colonization rates children are 25% 85%. Actually, rate known. What known about 10% 75% neonates first year life higher usually associated neonates. adults 5% 10%. However, incidence can be influenced diagnostic awareness clinicians. assume presence toxin implies disease as opposed colonization. agree it would interesting know course toxin-negative group well, view this weakness report. was retrospective study did information available analyze. addressing toxinnegative prospective, randomized, delayed treatment study.