Overcrowding drives the unjamming transition of gap-free monolayers

摘要: Collective cell motility plays central roles in various biological phenomena such as inflammatory response, wound healing, cancer metastasis and embryogenesis. These are demonstrations of the unjamming transition. However, contradictory to typical density-driven jamming processes particulate assemblies, cellular systems often get unjammed highly packed, sometimes overcrowding tissue environments. In this work, we report that can unjam gap-free monolayers through increasing isotropic compression. The transition boundary is determined by compression cell-cell adhesion. We explicitly construct free energy landscape for T1 topological during monolayer rearrangement, find it evolves from single-barrier shape double-barrier upon completion process. Our analyses reveal adhesion induced reflects mechanical yielding deformable monolayer, which differs those caused loosing up a packed assembly.