The role of plasma noradrenaline in health and disease

摘要: Abstract This paper proposes that plasma noradrenaline plays a central role in the physiology and pathophysiology of macrocirculation, heart, veins arteries. The proposal stems, final analysis, from finding dilates canine lateral saphenous vein when it is released its microcirculation, vasa venarum. concentration threshold effect estimated to be at least eight times lower than constrictor intralumenal noradrenaline. Combined with other evidence, indicates that, contrary opinion, has an effective β 1 -agonist hormonal on normal concentrations. It also bi-polar effect. reason primary biological stimulus like all stimuli investigated date, can expected have two cross-inhibitory components, commonly referred as excitor inhibitory. When examined, neuronal shows features characteristic components general those inhibitory components. most significant latter are potent physiological modulators A striking example modulation occurs smooth muscle contraction where muscles contracted by stimulation appear incapable relaxing without noradrenaline-hence proposition vascular stenosis cardiospasm caused pathological loss stimulation. By triggering turbulence, cholesterol plaques increase arterial microcirculatory flow so this driven cause arteriosclerotic syndrome, consistent success beta-blockade treating manifestations syndrome. concludes examining variety conditions, including dissecting aneurysms, dilator cardiac failure, angina, myocardial infarction, hypertension, eclampsia cirrhosis pointing out them, varicose veins, show evidence having been turbulence induced stimulatory