Making room for new faces: evolution, genomics and the growth of bioinformatics.

摘要: Genomics poses challenges that are specific to historians of science. Such not necessarily met by most recent sociologically-oriented approaches. This paper argues genomics can draw some lessons from the history molecular biology, in part because actors, concepts, and tools have made a transition between two fields. More importantly, face marginalization scientific fields actors played role integration both ultra-disciplines. While biochemistry genetics an underrated rising research on evolution informational molecules (molecular phylogenetics) neglected but nevertheless central development conceptual analytical bioinformatics for genomics. Even today genomic incorporate underlying assumptions show their origins problems comparative biology. is particularly true case algorithms sequence alignment, first proposed Needleman Wunsch (1970). The present essay also makes reference areas science require further investigation understanding transformations brought about biological research, namely, automation - beyond sequencing intersection biology mathematics.