Polycomb Complexes: Chromatin Regulators Required for Cell Diversity and Tissue Homeostasis
作者： Miguel Vidal
DOI: 10.1007/978-3-642-45198-0_5
关键词:
摘要: The Polycomb group (PcG) products are a set of evolutionary conserved proteins that form chromatin regulator complexes control expression developmentally relevant genes. PcG activity is essential not only to maintain the developmental potential pluripotent cells from which specialized cell types arise, but also ensure directionality differentiation process. In adult, these functions for normal homeostasis and their deregulation often associated with transformation events. PcG-dependent transcriptional involves posttranslational modifications histones, decreased DNA accessibility, other mechanisms. While stability Polycomb-determined landscapes rather stable in differentiated cells, it characteristically dynamic order accommodate execution genetic programs. Best known as repressors gene expression, recent evidence points at roles during activation. Besides control, participate such damage response, indicating involved wide spectrum cellular organismal need detailed characterization.
springer.com
sci-hub.st 参考文章(307)
Horst BLUTHMANN, Stanislav MROZEK, Alfred GIERER, Non-histone chromosomal proteins. Their isolation and role in determining specificity of transcription in vitro. FEBS Journal. ,vol. 58, pp. 315- 326 ,(1975) , 10.1111/J.1432-1033.1975.TB02378.X
Matthew L Bentley, Jacob E Corn, Ken C Dong, Qui Phung, Tommy K Cheung, Andrea G Cochran, Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. The EMBO Journal. ,vol. 30, pp. 3285- 3297 ,(2011) , 10.1038/EMBOJ.2011.243
Magnus D Lynch, Andrew J H Smith, Marco De Gobbi, Maria Flenley, Jim R Hughes, Douglas Vernimmen, Helena Ayyub, Jacqueline A Sharpe, Jacqueline A Sloane-Stanley, Linda Sutherland, Stephen Meek, Tom Burdon, Richard J Gibbons, David Garrick, Douglas R Higgs, An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment The EMBO Journal. ,vol. 31, pp. 317- 329 ,(2012) , 10.1038/EMBOJ.2011.399
John A. Hanover, Michael W. Krause, Dona C. Love, Bittersweet memories: linking metabolism to epigenetics through O -GlcNAcylation Nature Reviews Molecular Cell Biology. ,vol. 13, pp. 312- 321 ,(2012) , 10.1038/NRM3334
I L Goldknopf, C W Taylor, R M Baum, L C Yeoman, M O Olson, A W Prestayko, H Busch, Isolation and characterization of protein A24, a "histone-like" non-histone chromosomal protein. Journal of Biological Chemistry. ,vol. 250, pp. 7182- 7187 ,(1975) , 10.1016/S0021-9258(19)40926-5
E. de Wit, W. de Laat, A decade of 3C technologies: insights into nuclear organization Genes & Development. ,vol. 26, pp. 11- 24 ,(2012) , 10.1101/GAD.179804.111
Jueng Soo You, Daniel D. De Carvalho, Chao Dai, Minmin Liu, Kurinji Pandiyan, Xianghong J. Zhou, Gangning Liang, Peter A. Jones, SNF5 is an essential executor of epigenetic regulation during differentiation. PLOS Genetics. ,vol. 9, ,(2013) , 10.1371/JOURNAL.PGEN.1003459
Frédéric Bantignies, Virginie Roure, Itys Comet, Benjamin Leblanc, Bernd Schuettengruber, Jérôme Bonnet, Vanessa Tixier, André Mas, Giacomo Cavalli, Polycomb-dependent Regulatory Contacts Between Distant Hox Loci in Drosophila Cell. ,vol. 144, pp. 214- 226 ,(2011) , 10.1016/J.CELL.2010.12.026
Ismail Hassan Ismail, Christi Andrin, Darin McDonald, Michael J. Hendzel, BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair Journal of Cell Biology. ,vol. 191, pp. 45- 60 ,(2010) , 10.1083/JCB.201003034
K. Hisada, C. Sanchez, T. A. Endo, M. Endoh, M. Roman-Trufero, J. Sharif, H. Koseki, M. Vidal, RYBP Represses Endogenous Retroviruses and Preimplantation- and Germ Line-Specific Genes in Mouse Embryonic Stem Cells Molecular and Cellular Biology. ,vol. 32, pp. 1139- 1149 ,(2012) , 10.1128/MCB.06441-11