Effect of aging on human plasma growth hormone response to clonidine.
作者： Irit Gil-Ad , Rachel Gurewitz , Ozias Marcovici , Joseph Rosenfeld , Zvi Laron
DOI: 10.1016/0047-6374(84)90086-1
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摘要: The effect of the oral administration 0.150 mg/m2 clonidine on plasma level human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from to 68 years, which 15 were healthy volunteers 38 hypertensive. Both normal hypertensive subjects both sexes showed an age-related responsiveness hGH clonidine, with a or partial response younger blunting lack more elderly subjects. In females appeared at earlier age than males. It is speculated that alteration sensitivity central alpha-adrenergic receptors decrease sex steroid hormones may account for progressive reduction secretion advancing age.
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sci-hub.se 参考文章(10)
Spencer Berthelsen, William A. Pettinger, A functional basis for classification of α-adrenergic receptors Life Sciences. ,vol. 21, pp. 595- 606 ,(1977) , 10.1016/0024-3205(77)90066-2
Chandra H. Misra, Harnath S. Shelat, Robert C. Smith, Effect of age on adrenergic and dopaminergic receptor binding in rat brain Life Sciences. ,vol. 27, pp. 521- 526 ,(1980) , 10.1016/0024-3205(80)90134-4
I. MAANY, A. FRAZER, J. MENDELS, Apomorphine: effect on growth hormone. The Journal of Clinical Endocrinology and Metabolism. ,vol. 40, pp. 162- 163 ,(1975) , 10.1210/JCEM-40-1-162
David T. Lowenthal, Pharmacokinetics of clonidine. Journal of Cardiovascular Pharmacology. ,vol. 2, ,(1980) , 10.1097/00005344-198000021-00004
ANDREW G. FRANTZ, MITCHELL T. RABKIN, Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1 The Journal of Clinical Endocrinology and Metabolism. ,vol. 25, pp. 1470- 1480 ,(1965) , 10.1210/JCEM-25-11-1470
I. Gil-Ad, E. Topper, Z. Laron, ORAL CLONIDINE AS A GROWTH HORMONE STIMULATION TEST The Lancet. ,vol. 314, pp. 278- 280 ,(1979) , 10.1016/S0140-6736(79)90293-9
SAMARTHJI LAL, GEORGE TOLIS, JOSEPH B. MARTIN, GREGORY M. BROWN, HARVEY GUYDA, Effect of clonidine on growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone in the serum of normal men. The Journal of Clinical Endocrinology and Metabolism. ,vol. 41, pp. 827- 832 ,(1975) , 10.1210/JCEM-41-5-827
Mogens Blichert-Toft, Secretion of Corticotrophin and Somatotrophin by the Senescent Adenohypophysis in Man European Journal of Endocrinology. ,vol. 80, pp. 15- 154 ,(1975) , 10.1530/ACTA.0.080S0015
HAROLD E. CARLSON, J. CHRISTIAN GILLIN, PHILLIP GORDEN, FREDERICK SNYDER, Absence of Sleep-Related Growth Hormone Peaks in Aged Normal Subjects and in Acromegaly The Journal of Clinical Endocrinology and Metabolism. ,vol. 34, pp. 1102- 1105 ,(1972) , 10.1210/JCEM-34-6-1102
Z. Laron, M. Doron, B. Amikam, Plasma Growth Hormone in Men and Women over 70 Years of Age Karger Publishers. ,vol. 4, pp. 126- 131 ,(1969) , 10.1159/000387283