Retina thickness as a marker of neurodegeneration in prodromal lewy body disease.

摘要: Objectives We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort. Methods A total of 30 patients idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, brain N-(3-[18 F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane positron emission tomography. measured the ganglion cell complex thicknesses correlation function striatal dopamine transporter availability. linear mixed-effect model was applied adjustment for multiple comparisons. Results The parafoveal ganglion-cell-complex thickness this cohort lay between our healthy control drug-naive Parkinson's disease group data. Idiopathic also had impairment as nonsignificant sensitivities. Macular correlated scores availabilities. Conclusions thinning may be marker disease. © 2019 International Movement Disorder Society.