Comparative metabolism of warfarin in rats and chickens
作者： A. Saengtienchai , Y. Ikenaka , K. Watanabe , T. Ishida , M. Ishizuka
关键词:
摘要: ABSTRACT Warfarin, a coumarin rodenticide, is commonly used worldwide for rodent control, and often reported as the cause poisoning accidents in nontarget animals, particular bird species. However, metabolism of warfarin birds still unclear. In previous study, we found an unknown metabolite chicken cytosolic fractions. present aimed to clarify metabolites chickens compared with those rats. The cytosol fractions both rat livers showed metabolic activity 2 diastereomers enantiomers alcohol. cytosol, that production level (S)-warfarin-(S)-alcohol was markedly higher (32-fold) than cytosol. From results inhibition assay, finally suggest aldehyde oxidase may mainly contribute alcohol products
oup.com
fass.org参考文章(26)
Charles T. Eason, Elaine C. Murphy, Geoffrey R.G. Wright, Eric B. Spurr, Assessment of risks of brodifacoum to non-target birds and mammals in New Zealand. Ecotoxicology. ,vol. 11, pp. 35- 48 ,(2002) , 10.1023/A:1013793029831
L.S. Kaminsky, M.J. Fasco, F.P. Guengerich, Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin. Journal of Biological Chemistry. ,vol. 255, pp. 85- 91 ,(1980) , 10.1016/S0021-9258(19)86267-1
Yiu W. J. Wong, Patrick J. Davis, Microbial models of mammalian metabolism: stereoselective metabolism of warfarin in the fungus Cunninghamella elegans. Pharmaceutical Research. ,vol. 6, pp. 982- 987 ,(1989) , 10.1023/A:1015905832184
J.J.R. Hermans, H.H.W. Thijssen, The in vitro ketone reduction of warfarin and analogues. Substrate stereoselectivity, product stereoselectivity and species differences. Biochemical Pharmacology. ,vol. 38, pp. 3365- 3370 ,(1989) , 10.1016/0006-2952(89)90635-7
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Tsuneo Omura, Ryo Sato, The Carbon Monoxide-binding Pigment of Liver Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 2370- 2378 ,(1964) , 10.1016/S0021-9258(20)82244-3
Luisa Maia, Lurdes Mira, Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver. Archives of Biochemistry and Biophysics. ,vol. 400, pp. 48- 53 ,(2002) , 10.1006/ABBI.2002.2781
Ward B. Stone, Joseph C. Okoniewski, James R. Stedelin, POISONING OF WILDLIFE WITH ANTICOAGULANT RODENTICIDES IN NEW YORK Journal of Wildlife Diseases. ,vol. 35, pp. 187- 193 ,(1999) , 10.7589/0090-3558-35.2.187
Claire V. Dowding, Richard F. Shore, Andrew Worgan, Philip J. Baker, Stephen Harris, Accumulation of Anticoagulant Rodenticides in a Non-target Insectivore, the European hedgehog (Erinaceus europaeus) Environmental Pollution. ,vol. 158, pp. 161- 166 ,(2010) , 10.1016/J.ENVPOL.2009.07.017
Grover P. Miller, Drew R. Jones, Shane Z. Sullivan, Anna Mazur, Suzanne N. Owen, Neil C. Mitchell, Anna Radominska-Pandya, Jeffery H. Moran, Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans. Chemical Research in Toxicology. ,vol. 22, pp. 1239- 1245 ,(2009) , 10.1021/TX900031Z