Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish.

摘要: The treatment of psychiatric disorders presents three major challenges to the research and clinical community: defining a genotype associated with disorder, characterizing molecular pathology each disorder developing new therapies. This Review addresses how cellular animal systems can help meet these challenges, an emphasis on role zebrafish. Genetic changes account for large proportion and, as gene variants that predispose disease are beginning be identified in patients, tractable study systems. Defining criteria will uncover causal physiological patients lead more objective diagnostic criteria. These should also define co-morbid pathologies within nervous system or other organ definition genotypes any pathophysiology is integral development Cell culture-based approaches address by identifying high-throughput screening potential therapeutics. Whole-animal broadest function disorder-associated organismal impact candidate medications. Given its evolutionary conservation humans experimental tractability, zebrafish offers several advantages research. include assays ranging from behavioural, capability chemical screening. There optimism multiple discussed here link together effectively provide diagnostics treatments patients.