Gender Differences in the Relation between Fibrinogen, Tissue-type Plasminogen Activator Antigen and Markers of Insulin Resistance: Effects of Smoking

摘要: A stronger positive association between fibrinogen or tissuetype plasminogen activator antigen (tPA-ag) and fasting insulin is observed in women than men. We investigated whether this effect could be explained by a difference smoking habits. The relations markers for resistance [fasting as estimated the homeostasis model assessment (HOMA-IR)] tPA-ag were examined cross-sectionaly 4976 (582 tPA-ag) subjects from D.E.S.I.R. (Data an Epidemiological Study on Insulin Resistance syndrome) study. modifying of habits evaluated. Seventeen percent 27% men smokers. Fibrinogen concentrations higher smokers non-smokers, only. Female had lower non-smokers. In both men, was positively associated with [women: b = 0.33 mg/U (95% confidence interval: 0.29, 0.37); men: 0.15 (0.11, 0.19)] HOMA-IR b= 0.17 mg/mU mol/l (0.15, 0.19); 0.06 (0.04, 0.08)]. For these associations 0.76 (0.54, 0.98) 0.89 (0.67, 1.11), 0.47 (0.33, 0.61) 0.45 0.57), respectively. sharply reduced male compared to however strength non-smokers did not reach that women. are independetly related resistance, relation being strong does completely explain gender difference.