42 – HEMATOLOGY: COAGULATION PROBLEMS
作者： Sandor S. Shapiro , Stephen E.F. Spurgeon
DOI: 10.1016/B978-012433901-9/50045-4
关键词:
摘要: Lupus anticoagulants (LACs) are immunoglobulins that interfere with in vitro phospholipid-dependent coagulation tests. Initially recognized the context of systemic lupus erythematosus (SLE), LACs now known to occur frequently patients other disorders, as well individuals no apparent underlying disease. It is and anti-cardiolipin antibodies (ACAs) separate entities, but both members a diverse group bind phospholipid-bound proteins including, not limited to, β2-glycoprotein-I (β2GPI) prothrombin. ACAs associated high risk arterial venous thromboembolicevents, although mechanism this thrombotic still unknown. In chapter term “anti-phospholipid antibody (APL)” used denote presence LAC and/or ACA. The discusses diagnosis LACs, possible mechanisms APLs, treatment thrombosis APLs.
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