Process for the production of n-.beta.-hydroxyalkyl-tri-n-carboxyalkyl -1,4,7,10-tetraazacyclododecane and n-.beta.-hydroxyalkyl-tri-n-carboxyalkyl-1,4,8,11- tetraazacyclotetradecane derivatives and their metal compllexes

摘要: Process for producing N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives their metal complexes of general formula (I) in which R1 is a -(CH?2?)1-6-COOY group, possibly substituted by R?3, R2? group (a) n represents the figures 2 or 3, where existing hydroxy residues carboxy groups may be present protected form, reaction 1,4,7,10-tetraazacyclododecane 1,4,8,11-tetraazacyclotetradecane, form salts, presence base, with an epoxide (II), polar solvent without at temperatures 0 to 220 °C within 0.5 48 hours, base compound (III).