REGULATION OF EUKARYOTIC PROTEIN CHAIN INITIATION BY PROTEIN KINASES AND HEME
作者： Daniel Levin , Rajinder S. Ranu , Vivian Ernst , Hans Trachsel , Irving M. London
DOI: 10.1016/B978-0-08-022624-8.50009-0
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摘要: Publisher Summary This chapter describes the regulation of eukaryotic protein chain initiation by kinases and heme. Reticulocyte lysates provide a model system for studies on synthesis owing to several unique properties. They include an efficient rate initiation, extensive one major species, complete dependence exogenous hemin. In presence optimal concentrations added hemin, proceeds at linear rates prolonged periods. During period synthesis, polyribosomes are maintained, factors utilized catalytically. lysates, globin is comparable in vivo rate. absence control minutes, then declines abruptly yielding characteristic biphasic kinetics inhibition. The have established that inhibition mediated through translational inhibitor which rapidly activated
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