Searching the Mouse Genome Informatics (MGI) Resources for Information on Mouse Biology from Genotype to Phenotype.

作者: David Shaw

DOI: 10.1002/0471250953.BI0107S05

关键词:

摘要: The Mouse Genome Informatics (MGI, http://www.informatics.jax.org/) resource provides the research community with access to information on genetics, genomics, and biology of laboratory mouse. Core data in MGI include gene characterization function, phenotype disease model descriptions, DNA protein sequence data, expression mammalian orthologies, polymorphisms, mapping links other bioinformatics databases. Semantic integration is supported through use standardized nomenclature controlled vocabularies such as mouse Anatomical Dictionary Gene Ontologies. MouseBLAST offers a fast, sequence-based method for identifying genes searching similarity, from biological data. extracts organizes primary literature. are shared widely displayed by resources. database updated nightly curated annotations regularly adds new datasets enhances user interface features. This unit guide using resource. Keywords: mouse; genome; phenotypes; expression; genetics; mapping; polymorphisms; gene

参考文章(8)
Janan T. Eppig, Judith A. Blake, Donna L. Burkart, Carroll W. Goldsmith, Cathleen M. Lutz, Cynthia L. Smith, Corralling conditional mutations: a unified resource for mouse phenotypes. Genesis. ,vol. 32, pp. 63- 65 ,(2002) , 10.1002/GENE.10055
Jonathan B.L Bard, Matthew H Kaufman, Christophe Dubreuil, Renske M Brune, Albert Burger, Richard A Baldock, Duncan R Davidson, An internet-accessible database of mouse developmental anatomy based on a systematic nomenclature Mechanisms of Development. ,vol. 74, pp. 111- 120 ,(1998) , 10.1016/S0925-4773(98)00069-0
S Altschula, Warren Gisha, Webb Millerb, E Meyersc, D Lipmana, None, Basic Local Alignment Search Tool Journal of Molecular Biology. ,vol. 215, pp. 403- 410 ,(1990) , 10.1016/S0022-2836(05)80360-2
Judith A Blake, Joel E Richardson, Carol J Bult, Jim A Kadin, Janan T Eppig, MGD: the Mouse Genome Database. Nucleic Acids Research. ,vol. 31, pp. 193- 195 ,(2003) , 10.1093/NAR/GKG047
S Asburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel‐Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock, Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genetics. ,vol. 25, pp. 25- 29 ,(2000) , 10.1038/75556
David P Hill, Judith A Blake, Joel E Richardson, Martin Ringwald, Extension and integration of the gene ontology (GO): combining GO vocabularies with external vocabularies. Genome Research. ,vol. 12, pp. 1982- 1991 ,(2002) , 10.1101/GR.580102
Cynthia L Smith, Carroll-Ann W Goldsmith, Janan T Eppig, The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information. Genome Biology. ,vol. 6, pp. 1- 9 ,(2004) , 10.1186/GB-2004-6-1-R7
Martin Ringwald, Janan T Eppig, Dale A Begley, John P Corradi, Ingeborg J McCright, Terry F Hayamizu, David P Hill, James A Kadin, Joel E Richardson, The Mouse Gene Expression Database (GXD) Nucleic Acids Research. ,vol. 29, pp. 98- 101 ,(2001) , 10.1093/NAR/29.1.98