Transcutaneous application of nicotine

摘要: Percutaneous administration of nicotine in a dose approximating the delivered by variety nicotine-­containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The so to mimic pharmacological effects provided conventional use therapeutic function achieved reducing or eliminating need for tobacco product. A suitable transdermal application pad (10) comprises reservoir (14) liquid base (16) be affixed skin places. Due high lipid solubility resultant permeability nicotine, vehicles solvents are not generally needed enhance dermal absorption.