摘要: Oxygen free radicals and other oxidants are causing potential danger for intracellular proteins during the lifetime of cells organisms. Therefore, protein oxidation is one natural consequences aerobic life. The degradation non-functional, oxidized an essential part antioxidant defenses cells. major proteolytic system responsible removal cytosolic proteasomal system. This consists 20S 'core' proteasome a multitude various regulators. It known that certain components this regulated oxidative stress aging. One highlights age-related changes cellular metabolism accumulation proteins. question whether aging due to malfunction machinery cell remains still unsolved. information available about decline very contradictory. current literature system, regulation in focus review.
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