Retinal Vasculature Reactivity During Flicker Light Provocation, Cardiac Stress and Stroke Risk in Africans: The SABPA Study.

摘要: Structural and functional similarities exist between the retinal, cerebral and, as previously suggested, coronary microvasculature. Retinal microvascular structure functionality (in response to flicker-light-induced-provocation (FLIP)) may relate artery disease risk possible stroke risk. We investigated associations retinal vessel structure, cardiac stress markers (cardiac troponin T [cTnT], amino-terminal B-type natriuretic peptide [NT-proBNP]) translate these retina–heart relationships included 317 African Caucasian teachers’ (aged 23–68 years), who participated in Sympathetic Activity Ambulatory Blood Pressure Africans (SABPA) study. Fasting plasma serum samples for cTnT NT-proBNP were collected. vascular calibres quantified from fundus images dynamic calibre responses during FLIP. The University of California score was applied assess sub-clinical 10-year levels similar Caucasians, whereas lower Africans. In Africans, a reduced arteriolar attenuated dilation FLIP associated with higher (p < 0.01). Their larger retinal–venular (p < 0.02) (p < 0.05) NT-proBNP. Again, exclusively increased stress, wider venular arteriovenous nicking predicted an odds ratios 1.57 (95% CI, 1.34; 1.68, p = 0.031), 1.51 1.26; 1.59, p = 0.002), 1.10 0.94; 2.85, p = 0.002) 1.06 CI 0.83; 1.56, p = 0.052), respectively. None evident group. Investigating vasculature serve tool approximate microvasculature damage or dysfunction. These stress–retinal additionally greater SABPA cohort. Observable changes identification prediction cardio-systemic morbidities risks, thereby establishing brain-heart link.