Engineered lactose carrier particles with enhanced microstructure giving improved inhaler performance

摘要: The primary function of a carrier particle in dry powder Inhaler (DPI) is to improve the flow otherwise cohesive micronized drug particles. aids during manufacture and operation, i.e. including mixing transport, metering dispersion. Traditional such carriers are general between about 50 150 pm size, provide required (1), typically take form 'Tomahawk' clystalline shape. However these conventional hate significant limitations. They can suffer poor once mixed with more than 10 20% w/w material, whereby bulk cohesion banes too great, due carrying surface becoming saturated presence loose fines. Previously, same efforts have been made address this dose restriction, either developing much smaller, treated (2), or employing larger comprising an agglomerated structure (3). This latter approach has relied on modified rugosity complex open which appears suited absorb fine components, resulting structured pellet-like formulation. Recently, novel direct (4) was developed pilot-scale engineer specialist lactoses very high reduced density via single crystallization step. current study examine potential alternative high-performance particles for use DPIs.