Preservative free insulin formulations

作者: Yehuda Ivri , Mei-chang Kuo , John S. Patton , Ryan S. Patton

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摘要: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The includes a major amount of water and minor insulin. Further, the preservative free, without meta-cresol, cresol or phenol, to permit be aerosolized using vibrating aperture plate substantial foaming formulation.

参考文章(71)
Jens Brange, Liselotte Langkj\sgmaelig;r, Svend Havelund, Aage Vølund, Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations Pharmaceutical Research. ,vol. 9, pp. 715- 726 ,(1992) , 10.1023/A:1015835017916
Fang‐yu Liu, Zezhi Shao, Dane O. Kildsig, Ashim K. Mitra, Pulmonary Delivery of Free and Liposomal Insulin Pharmaceutical Research. ,vol. 10, pp. 228- 232 ,(1993) , 10.1023/A:1018934810512
Yehuda Ivri, Mei-chang Kuo, John S. Patton, Ryan S. Patton, Preservative free insulin formulations and systems and methods for aerosolizing ,(2011)
Liselotte Langkjaer, Formulations of insulin ,(2005)
Michael Thomas Kane, Gregory Delano Matthews, Benjamin Irwin Shelly, Servo ventilation using negative pressure support ,(2010)
Ryan S. Patton, John Patton, Inhaler controlled by mobile device ,(2013)