Propofol-Nitrous Oxide Versus Thiopental-isoflurane-nitrous Oxide for General Anesthesia

摘要: One hundred and twenty patients undergoing elective operations were randomly assigned to receive anesthesia with either thiopental, 4 mg/kg-isoflurane, 0.2-3%-nitrous oxide, 60-70% (control) or propofol, 2 mg/kg-propofol infusion, 1-20 mg/min-nitrous (propofol). Although anesthetic conditions similar during the operation, differences noted in recovery characteristics. For non-major (superficial) surgical procedures, times awakening, responsiveness, orientation, ambulation significantly shorter propofol group (4 +/- 3, 5 4, 6 104 36 min) than control (8 7, 9 11 9, 142 61 min, respectively). In addition, less nausea vomiting (20 vs. 45%) psychomotor impairment was (vs. control) group. Following major abdominal operations, characteristics did not differ between groups. Delayed emergence (greater 20 min), significant psychometric impairment, a high overall incidence of postoperative side effects (55-60%) both drug treatment The authors conclude that propofol-nitrous oxide compares favorably thiopental-isoflurane-nitrous for maintenance short outpatient procedures. However, does appear offer any clinically advantages over standard inhalational technique.