Host-guest complexes as water-soluble high-performance DNP polarizing agents.
作者： Jiafei Mao , Dmitry Akhmetzyanov , Olivier Ouari , Vasyl Denysenkov , Björn Corzilius
DOI: 10.1021/JA409840Y
关键词:
摘要: Dynamic nuclear polarization (DNP) enhances the sensitivity of solid-state NMR (SSNMR) spectroscopy by orders magnitude and, therefore, opens possibilities for novel applications from biology to materials science. This multitude opportunities implicates a need high-performance polarizing agents, which integrate specific physical and chemical features tailored various applications. Here, we demonstrate that biradical bTbK in complex with captisol (CAP), β-cyclodextrin derivative, host–guest assembling offers new easily accessible approach development agents. In contrast bTbK, CAP-bTbK is water-soluble shows significantly improved DNP performance compared commonly used agent TOTAPOL. Furthermore, EPR data reveal electron spin relaxation properties within host molecule. The numerous functionalize molecules will permit designing radical complexes targeting...
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