The Cell Cycle

摘要: Dysregulation of cell cycle signaling is a pathognomonic feature tumor initiation and progression. An understanding the key components dysregulated in cancer molecular mechanisms responsible has led to generation new targeted therapeutics. The development therapies which selectively inactivate genetic drivers specific tumors use abnormalities within activate exemplify mechanism-based therapies. tyrosine kinase inhibitor signal transduction inhibitor-571 (STI-571) prototypic molecular-targeted therapy, targets aberrant Bcr-Abl activity produces highly anti-cancer effect chronic myelogenous leukemia (CML) patients. Novel include inhibitors kinases, cyclin-dependent kinases or histone deacetylases, lytic viruses that kill cells with defective p53 function, mimics induce recapitulate endogenous suppressors. These approaches are derived from an control drive tumorigenesis. Components often play distinct roles biological processes normal development, progression adult animal, during process realization redundant embryogenesis, but required for tumorigenesis, provides additional, compelling rationale targeting cancer. Ultimately, continued study used by cancerous evade checkpoint groundwork rational aimed at improving both efficacy treatment quality patient life.