Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation.

摘要: Abstract Objective A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported significant association between early childhood levels and response to acute stress. The current study considers the autonomic nervous system activation pattern underlying stress new cohort children. Methods We assessed blood as well responses 9–11 year old children ( N  = 140). Sympathetic (measured with pre-ejection period) parasympathetic high frequency heart rate variability) were also assessed. Results In sample very low M  = 1.01 μg/dL), found increasing was associated coinhibition sympathetic addition, hemodynamic typical — significantly greater vascular resistance reduced stroke volume cardiac output. Conclusions Blood dysregulation psychological Moreover, these effects at considered be notably below 10 μg/dL, Centers Disease Control Prevention definition an elevated level. many US would potentially broad public health ramifications.