NMR of the Enaminones
作者： Patrice L. Jackson-Ayotunde , Ivan O. Edafiogho , Mariano S. Alexander , Kenneth R. Scott
DOI: 10.1016/B978-1-68108-063-5.50005-9
关键词:
摘要: Abstract: Nuclear Magnetic Resonance (NMR) spectroscopy has advanced as an important tool in support of several studies pharmacological interest. In this chapter, the following sections are discussed: history NMR spectroscopy, enaminone derivatives and their NMR, use molecular modeling techniques adjunct to analysis, a newer class compounds, sulfonamide enaminones intermolecular forces determined via X-ray crystallography. The details field its origin, utilization area structure identification. section on gives detailed look into analyzing various analogs, including our library anticonvulsant enaminones. Examples include work Zhou noting correlation between 17O (which natural abundance) chemical shifts carbonyl atom 1H shifts. Our analogs was complemented by with examples how reactions were analyses. aspects explains Gaussian 03 performs suitable functions determining final reason why some compounds series more potent than others. illustrates sulfonamido now being researched potential agents profile (having 6 Hz ‘psychomotor’ activity) differs from previously investigated derivatives.
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