Expression of tyrosine hydroxylase in cerebellar Purkinje cells of ataxic mutant mice: its relation to the onset and/or development of ataxia.

摘要: This report describes recent studies on tyrosine hydroxylase (TH) expression in Purkinje cells of the cerebellum ataxic mutant mice. An increased TH some has been observed two allelic groups mice, tottering and dilute. TH-positive appeared preceding onset ataxia. Northern blot analysis revealed 2.1 kb mRNA cerebella, size was identical to that transcripts other brain regions. However, did not seem participate catecholamine biosynthesis. In vitro showed cultured non-catecholaminergic neurons expressed following Ca2+ influx. Therefore, abnormal may indicate neuronal dysfunction caused by misregulation intracellular concentrations.