Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.

摘要: Aims The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is basis their therapeutic eYcacy. There still controversy as to whether these agents are capable direct by diVusion through or redistribution in systemic circulation responsible for tissue deposition application site. Methods extent salicylate commercial ester and salt formulations dermal subcutaneous human volunteers was determined using technique cutaneous microdialysis. We also examined diVerences hydrolysis methylester vitro cells full-thickness epidermal membranes. Results present study showed that whilst significant levels could be detected dermis treated with methylsalicylate formulation, negligible were seen following triethanolamine formulation. formulation approx. 30-fold higher than plasma concentrations. absorption concentration profiles indicative not solely blood supply.