Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study
作者： Arlene E Garcia-Soto , James J Java , Wilberto Nieves Neira , J Matthew Pearson , David E. Cohn
DOI: 10.1016/J.YGYNO.2016.10.003
关键词:
摘要: Abstract Objectives To determine the relationship of time from surgery to intraperitoneal (IP) chemotherapy (TSIC) initiation with survival patients stage III epithelial ovarian cancer (EOC) using ancillary data cooperative group clinical trials. Methods Data 420 EOC treated IP under GOG-0114 and 172 were reviewed. The Cox proportional hazards model was used evaluate independent prognostic factors estimate their covariate-adjusted effects on PFS OS. Results median TSIC 62.5days (interquartile range 28–83). longer for in vs those GOG-172 (83 26days, p 2 −0.141, 95%CI −0.217, −0.064, Conclusions In this study, not associated improved OS cancer. significantly entire cohort, suggesting increase TSIC. However, found when only GOG or 114 analyzed separately. Hence, between needs be studied further.
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