Tobacco Smoke Hemoglobin Adducts in Maternal and Fetal Blood
作者： Steven R. Myers , Joseph A. Spinnato , Maria T. Pinorini-Godly
DOI: 10.1080/10406630008028531
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摘要: Abstract The maternal-fetal exchange of the potent tobacco related human carcinogen, 4-aminobiphenyl, was studied in women smokers during pregnancy. Maternal and fetal blood samples were classified as coming from nonsmokers (n=74), individuals smoking less than 1 pack cigarettes per day (n=16), (n=19), 1–2 packs greater 2 (n=20). 4-Aminobiphenyl extracted both maternal using organic extractions released amine qualitatively quantitatively characterized by analysis gas chromatographic mass spectrometric analysis. Increasing levels 4-aminobiphenyl - hemoglobin adducts found status increased ranging 144 ± 22.2 ( day). A corresponding increase presence adduct...
sci-hub.se 参考文章(33)
Kadlubar Ff, Butler Ma, Guengerich Fp, Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. Cancer Research. ,vol. 49, pp. 25- 31 ,(1989)
R. M. Disher, Leejane Lu, K. Randerath, M. V. Reddy, 32P-Postlabeling Assay in Mice of Transplacental DNA Damage Induced by the Environmental Carcinogens Safrole, 4-Aminobiphenyl, and Benzo(a)pyrene Cancer Research. ,vol. 46, pp. 3046- 3054 ,(1986)
Helen Van Vunakis, John J. Langone, Aubrey Milunsky, Nicotine and cotinine in the amniotic fluid of smokers in the second trimester of pregnancy American Journal of Obstetrics and Gynecology. ,vol. 120, pp. 64- 66 ,(1974) , 10.1016/0002-9378(74)90180-X
Shirley L. Kauffman, Susceptibility of Fetal Lung to Transplacental 1-Ethyl-1-nitrosourea: Its Relation to Epithelial Proliferation
2 JNCI: Journal of the National Cancer Institute. ,vol. 57, pp. 821- 825 ,(1976) , 10.1093/JNCI/57.4.821
Michael Stjernfeldt, Jan Lindsten, Kenneth Berglund, Johnny Ludvigsson, FOR THE SWEDISH CHILD LEUKEMIA GROUP, OF SOLID TUMOURS IN CHILDREN, MATERNAL SMOKING DURING PREGNANCY AND RISK OF CHILDHOOD CANCER The Lancet. ,vol. 327, pp. 1350- 1352 ,(1986) , 10.1016/S0140-6736(86)91664-8
D P Sandler, R B Everson, A J Wilcox, J P Browder, Cancer risk in adulthood from early life exposure to parents' smoking American Journal of Public Health. ,vol. 75, pp. 487- 492 ,(1985) , 10.2105/AJPH.75.5.487
H. Druckrey, R. Preussmann, S. Ivankovic, N-NITROSO COMPOUNDS IN ORGANOTROPIC AND TRANSPLACENTAL CARCINOGENESIS Annals of the New York Academy of Sciences. ,vol. 163, pp. 676- 695 ,(1969) , 10.1111/J.1749-6632.1969.TB24886.X
J. Coghlin, P. H. Gann, S. K. Hammond, P. L Skipper, K. Taghizadeh, M. Paul, StevenR. Tannenbaum, 4-Aminobiphenyl hemoglobin adducts in fetuses exposed to the tobacco smoke carcinogen in utero. Journal of the National Cancer Institute. ,vol. 83, pp. 274- 280 ,(1991) , 10.1093/JNCI/83.4.274
Nicola Smith, Jennifer Austen, ChristopherJ. Rolles, TERTIARY SMOKING BY THE FETUS The Lancet. ,vol. 319, pp. 1252- ,(1982) , 10.1016/S0140-6736(82)92382-0
A.K.M. Shamsuddin, R. Gan, Immunocytochemical localization of benzo(a)pyrene-DNA adducts in human tissues Human Pathology. ,vol. 19, pp. 309- 315 ,(1988) , 10.1016/S0046-8177(88)80524-0