Chemokine Receptor CXCR3: An Unexpected Enigma
作者： Liping Liu , Melissa K. Callahan , DeRen Huang , Richard M. Ransohoff
DOI: 10.1016/S0070-2153(05)68006-4
关键词:
摘要: CXCR3, the receptor for CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC, is preferentially expressed on activated Th1 T cells has been predicted to play an important role in their trafficking. However, this simplistic view of function CXCR3 its ligands not borne out by studies disease models, including experimental autoimmune encephalomyelitis (EAE), using varied methods blockade, as well knockout or transgenic mice. This review focuses current understanding enigmatic CNS inflammatory/autoimmune disorders. The conflicting results among models inflammation suggest complex multiple roles pathogenesis diseases. Thus, further study needed determine how CXCL10 neutralizing agents antagonists might be applied treating human disease.
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