Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.

作者: AP Schmidt , AE Böhmer , C Antunes , C Schallenberger , LO Porciúncula

DOI: 10.1111/J.1476-5381.2008.00025.X

关键词:

摘要: … We hypothesized that the inhibition of xanthine oxidase by allopurinol, thereby reducing … of allopurinol on chemical and thermal pain models in mice. Experimental approach: Mice …

参考文章(67)
Mirna Bainy Leal, Diogo O. G. de Souza, Elaine Elisabetsky, Long-lasting ibogaine protection against NMDA-induced convulsions in mice. Neurochemical Research. ,vol. 25, pp. 1083- 1087 ,(2000) , 10.1023/A:1007665911622
Dietrich Van Calker, Jens Timmer, Florian Christoffel, Hinnak Northoff, Peter J Gebicke-Haerter, Mathias Berger, Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation Neurochemistry International. ,vol. 29, pp. 37- 42 ,(1996) , 10.1016/0197-0186(95)00137-9
James M. Brundege, Thomas V. Dunwiddie, Role of Adenosine as a Modulator of Synaptic Activity in the Central Nervous System Advances in pharmacology. ,vol. 39, pp. 353- 391 ,(1997) , 10.1016/S1054-3589(08)60076-9
Gary J Bennett, Update on the Neurophysiology of Pain Transmission and Modulation: Focus on the NMDA-Receptor Journal of Pain and Symptom Management. ,vol. 19, pp. 2- 6 ,(2000) , 10.1016/S0885-3924(99)00120-7
Jana Sawynok, Adenosine receptor activation and nociception European Journal of Pharmacology. ,vol. 347, pp. 1- 11 ,(1998) , 10.1016/S0014-2999(97)01605-1
Ahmet Hacimuftuoglu, CR Handy, VM Goettl, CG Lin, S Dane, RL Stephens Jr, Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice. Behavioural Brain Research. ,vol. 173, pp. 211- 216 ,(2006) , 10.1016/J.BBR.2006.06.030
Jean Pierre Oses, Renata Leke, Luis Valmor Portela, Diogo R. Lara, André P. Schmidt, Emerson André Casali, Susana Wofchuk, Diogo O. Souza, João José Freitas Sarkis, Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Brain Research Bulletin. ,vol. 64, pp. 237- 242 ,(2004) , 10.1016/J.BRAINRESBULL.2004.07.006
Guillermo Ceballos, Jeremy B. Tuttle, Rafael Rubio, Differential distribution of purine metabolizing enzymes between glia and neurons. Journal of Neurochemistry. ,vol. 62, pp. 1144- 1153 ,(2008) , 10.1046/J.1471-4159.1994.62031144.X
André P. Schmidt, Diogo R. Lara, Diogo O. Souza, Proposal of a guanine-based purinergic system in the mammalian central nervous system. Pharmacology & Therapeutics. ,vol. 116, pp. 401- 416 ,(2007) , 10.1016/J.PHARMTHERA.2007.07.004
Takiko Matsuo, Hiroshi Tada, Keiichi Morooka, Kiyoshi Arimoto, Clinical Effects of Allopurinol on Intractable Epilepsy Epilepsia. ,vol. 32, pp. 279- 283 ,(1991) , 10.1111/J.1528-1157.1991.TB05256.X