Timely Versus Delayed Early Childhood Vaccination and Seizures
作者： S. J. Hambidge , S. R. Newcomer , K. J. Narwaney , J. M. Glanz , M. F. Daley
关键词:
摘要: BACKGROUND: Little is known regarding the timing of childhood vaccination and postvaccination seizures. METHODS: In a cohort 323 247 US children from Vaccine Safety Datalink born 2004 to 2008, we analyzed association between first occurrence seizure with self-controlled case series analysis doses individual vaccines received in 2 years life. RESULTS: infants, there was no infant second year life, incident rate ratio (IRR) for seizures after receipt measles-mumps-rubella vaccine (MMR) dose at 12 15 months 2.65 (95% confidence interval [CI] 1.99–3.55); IRR an MMR 16 23 6.53 CI 3.15–13.53). The measles-mumps-rubella-varicella (MMRV) 4.95 3.68–6.66); MMRV 9.80 4.35 –22.06). CONCLUSIONS: There increased risk infants regardless vaccination. 2, delaying past age results higher strength doubled vaccine. These findings suggest that on-time as safe regard delayed life associated more than
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