A novel method for nucleic acid sequence determination
作者： William Bains , Geoff C. Smith
DOI: 10.1016/S0022-5193(88)80246-7
关键词:
摘要: We describe a novel sequencing methodology which should be readily and completely automated. The method relies on fragmentation of nucleotide or deoxynucleotide sequence into short fragments, subsequent quantitation the fragments by hybridization to oligo-deoxynucleotides solid support. original may reconstructed from resulting table fragment frequencies. present specific protocol would allow practical implementation this approach.
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