Chapter 10 – Role of Oxidative Stress in Neurodegenerative Diseases and Other Diseases Related to Aging
作者： Amitava Dasgupta , Kimberly Klein
DOI: 10.1016/B978-0-12-405872-9.00010-0
关键词:
摘要: The free radical theory of aging, proposed in the 1950s by Denham Harman, postulated that oxygen radicals formed endogenously from normal metabolic processes play a role aging process due to an increase oxidative damage macromolecules. This has since been modified and is now called stress because other species, such as peroxides aldehydes, can induce are not technically radicals. Damage macromolecules related loss optimal function various organs aging. Oxidative also directly premature chapter presents current knowledge linking process. plays important onset human neurovegetative diseases, including Alzheimer’s disease Parkinson’s disease. particular associated with accumulation many markers stress, demonstrated precede formation lesions brain symptoms. Clinical depression anxiety produced both nitrogen
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