Pharmacology of Thyrotropin Releasing Factor (TRF), Luteinizing Hormone Releasing Factor (LRF), and Somatostatin

作者: Wylie Vale , Catherine Rivier , Marvin Brown , Jean Rivier

DOI: 10.1007/978-1-4615-8849-8_7

关键词:

摘要: It is now apparent that the three characterized hypothalamic hypo-physiotropic regulatory peptides have powerful biological activities on pituitary gland, central nervous system, and, in case of somatostatin, gastrointestinal tract and pancreas. The distribution these a variety immunological, physiological, clinical studies suggested possess important physiological functions each organ systems could, under some circumstances, play pathophysiologic roles as well. In order to study exploit biologically peptides, synthetic analogs been developed which can be used for several investigational purposes.

参考文章(63)
Luis Schwarzstein, Diagnostic and therapeutic use of LH-RH in the infertile man. Current topics in molecular endocrinology. ,vol. 3, pp. 73- 91 ,(1976) , 10.1007/978-1-4684-2598-7_6
Barbara Petrack, Andrew J. Czernik, William Itterly, Justin Ansell, Herbert Chertock, Diazepam: Invitro effects on glucagon and insulin release Biochemical and Biophysical Research Communications. ,vol. 73, pp. 934- 939 ,(1976) , 10.1016/0006-291X(76)90211-4
Marcella Motta, Luciano Martini, P. G. Crosignani, Hypothalamic hormones: Chemistry, physiology, pharmacology and clinical uses ,(1975)
Wylie Vale, Catherine Rivier, Hypothalamic Hypophysiotropic Hormones Springer US. pp. 195- 238 ,(1975) , 10.1007/978-1-4684-3177-3_4
Patricia M. Hinkle, Eugene L. Woroch, Armen H. Tashjian, Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture. Journal of Biological Chemistry. ,vol. 249, pp. 3085- 3090 ,(1974) , 10.1016/S0021-9258(19)42641-0
Wylie W. Vale, Jean E. F. Rivier, Marvin R. Brown, Somatostatin analogs with dissociated biological activities ,(1977)
V. Höllt, J. Dum, J. Bläsig, P. Schubert, A. Herz, Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant/dependent rodents Life Sciences. ,vol. 16, pp. 1823- 1828 ,(1975) , 10.1016/0024-3205(75)90284-2
V.M. Garsky, D.E. Clark, N.H. Grant, Synthesis of a nonreducible cyclic analog of somatostatin having only growth hormone release inhibiting activity Biochemical and Biophysical Research Communications. ,vol. 73, pp. 911- 916 ,(1976) , 10.1016/0006-291X(76)90208-4
Cyril Y. Bowers, Yieh-Ping Wan, John Humphries, Karl Folkers, Studies on inhibition of the luteinizing hormone-releasing hormone by an irreversible inhibitor at the receptor site Biochemical and Biophysical Research Communications. ,vol. 61, pp. 698- 703 ,(1974) , 10.1016/0006-291X(74)91013-4