The effect of ω‐conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro

摘要: 1. The actions of two calcium channel antagonists, the N-channel blocker omega-conotoxin GVIA (omega-CgTx) and L-channel antagonist nisoldipine, on synaptic transmission were investigated in hippocampus nucleus accumbens rat vitro. 2. omega-CgTx (100 nM for 10 min) produced a marked irreversible reduction focally evoked population spikes intracellularly recorded excitatory postsynaptic potentials (e.p.s.ps) accumbens, which could not be overcome by increasing stimulus strength. 3. Nisoldipine (10 microM had no effect or CA1 hippocampus. 4. In hippocampus, irreversibly reduced but rather, multiple along with spontaneous synchronous discharges. This indicated that inhibitory was being preferentially reduced. 5. Intracellular recordings demonstrated powerfully an manner also to lesser extent. Unlike strength overcame hippocampal transmission. 6. It is concluded omega-CgTx-sensitive channels are involved entry precedes all these synapses. apparent lower sensitivity fibres may indicate promotes transmitter release at central synapses mediated pharmacologically distinct channels.